Your body also has two key hormones it uses to regulate hunger: ghrelin and leptin. Ghrelin is produced by the stomach, and signals to the brain to increase your appetite when the stomach is empty and energy is needed. Leptin is produced by your fat cells and does the opposite, working to increase metabolism for digestion and signaling to the brain that you are full, and no more food is needed.
Nutritional ketosis induced by carbohydrate restriction is often associated with major weight loss, which raises some important questions. Do ketones cause weight loss? Do ketones promote a metabolic condition whereby fat melts away to a greater extent than a non-ketogenic diet of equal energy content?  Alternatively, can a person maintain or even gain weight while in nutritional ketosis?  To explore the answers to these questions, we need to venture into the complex inter-relationships between keto-adaptation, appetite, energy balance and weight loss.
Whether you’re falling victim to chub rub, hate hearing the thunderous round of applause your legs give you when you run in shorts, or just don’t like going to battle with your jeans day after day, there are plenty of good reasons to make slimming down your lower half a top priority. They say thick thighs save lives, but strong, toned ones may be the key to a longer, more active life.
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